Liver cancer is the sixth most commonly diagnosed cancer worldwide in 2018, with about 841,000 new cases.
new cases diagnosed each year
Liver cancer is the fourth leading cause of cancer death per year in the world after Lung, Colorectum & Stomach, representing 8.2% of all cancer deaths (782 000 deaths) (1)
of all cancer deaths
There are three main types of primary liver cancer. The most common type is hepatocellular carcinoma (HCC) accounting for 75-90% of liver cancers.
Worldwide, approximately 54% of cases can be attributed to Hepatitis B virus (HBV) infection while 31% can be attributed to Hepatitis C virus (HCV) infection, leaving approximately 15% associated with other causes 2.
The main types of secondary liver cancer are from:
• Colorectal cancer (the most common)
• Neuroendocrine tumors
• Uveal melanoma
• Breast cancer
Diagnosis of HCC in cirrhotic patients should be based on non-invasive criteria and/or pathology. In non-cirrhotic patients, diagnosis of HCC should be confirmed by pathology. Non-invasive criteria can only be applied to cirrhotic patients for nodule(s) ≥1 cm, in light of the high pre-test probability and are based on imaging techniques obtained by multiphasic CT, dynamic contrast-enhanced MRI or CEUS (2).
1 WHO-cancer today, Source: Globocan 2018
2 EASL-EORTC Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma. J. Hepatol. 2018